Department of Dermatology and Venerology, University Hospital of Cologne
Cluster of Excellence - Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Cells in a developing organism or tissue are faced with multiple fate choices. However, they do adopt specific fates in a very reproducible manner. Just like a computer program initiates a sequence of events where one leads to another, cells follow a defined path to arrive at their pre-determined fates.
Our main interest is to decipher this complex cellular program with a focus on signaling pathways and cytoskeletal organization.
In order to study cell fate decisions, our lab primarily uses genetic approaches in the mouse, as a model organism. In addition, we utilize cells in vitro such as mouse embryonic stem cells (mESCs) and primary cell culture to investigate the mechanisms that are difficult to address in the mouse in vivo. Our lab employs cutting edge techniques of gene editing such as the CRISPR/Cas9 system and proteomics and transcriptomics in our studies.